摘 要：
目的：探讨妊娠期糖尿病（GDM）患者血清和胎盘中白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）、细胞间黏附分子-1（ICAM-1）的表达水平并分析其相关性。方法：选取2022 年 7 月至 2023 年 6 月在我院产科分娩的 GDM 患者 50 例作为研究组，选择同一时间正常妊娠孕妇 50 例作为对照组。比较两组血清和胎盘中 IL-1β、TNF-α和ICAM-1水平，并分析GDM 患者这三种指标表达的相关性。结果：研究组血清和胎盘中 IL-1β、TNF-α和ICAM-1水平均明显高于对照组（P＜0.05）。相关性分析结果显示：GDM 患者血清和胎盘中 IL-1β 与 TNF-α、ICAM-1 表达均呈正相关，TNF-α 与 ICAM-1 表达也呈正相关（P<0.05）。结论：GDM 患者血清和胎盘组织中IL-1β、TNF-α和ICAM-1均高表达，且三者表达密切相关，可能通过协同作用参与 GDM患者胎盘血管内皮损伤的病理过程。
关键词：妊娠期糖尿病；白细胞介素-1β；肿瘤坏死因子-α；细胞间黏附分子-1
Abstract:
Objective: To investigate the expression levels of interleukin-1 β (IL-1 β), tumor necrosis factor - α (TNF - α) and intercellular adhesion molecule-1 (ICAM-1) in serum and placenta of pregnant women with diabetes mellitus (GDM) and analyze their correlation.Method: 50 GDM patients who gave birth in our obstetrics department from July 2022 to June 2023 were selected as the study group, and 50 normal pregnant women at the same time were selected as the control group. Compare the levels of IL-1 β, TNF - α, and ICAM-1 in two groups of serum and placenta, and analyze the correlation between the expression of these three indicators in GDM patients.Result: The levels of IL-1 β, TNF - α, and ICAM-1 in the serum and placenta of the study group were significantly higher than those in the control group (P<0.05). The correlation analysis results showed that the expression of IL-1 β, TNF - α, and ICAM-1 in the serum and placenta of GDM patients were positively correlated, and the expression of TNF - α and ICAM-1 was also positively correlated (P<0.05).Conclusion: IL-1 β, TNF - α, and ICAM-1 are all highly expressed in the serum and placental tissue of GDM patients, and their expression is closely related. They may participate in the pathological process of placental endothelial injury in GDM patients through synergistic effects.
Keywords: Gestational diabetes; Interleukin-1 β; Tumor necrosis factor - α; Intercellular adhesion molecule-1
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