Objectives: Embryo development is a very complex and finely regulated process. Embryo culture not only requires a good culture medium system, but also depends on the entire air environment of the in vitro fertilization laboratory. In 2017, the Cairo International Expert Meeting on assisted Reproductive Technology reached dozens of conssions on the technical and operation aspects of laboratory air quality, including the location of assisted reproductive laboratories, the design standards of new facilities, laboratory commissioning, and the continuous management of volatile organic compounds, which provided a reference for existing laboratories and guidance for new laboratories. Based on the international expert consensus on volatile organic compounds in human assisted reproductive laboratory environment and the current situation in China, we searched the literature on whether and how the laboratory pollutants (volatile organic compounds) affect oocyte fertilization and embryo development, and summarized the types, sources, possible harmful effects and environmental quality control of volatile organic compounds in laboratory. Different types of vocs may affect cellular structure and cell communication, alter specific gene expression, and make them more susceptible to genetic mutations. At the same time, volatile organic compounds may have adverse effects on oocyte fertilization, blastocyst development, hatching and implantation, which are negatively correlated with clinical outcomes.
Keywords: Volatile organic compounds; Quality control; Development of embryos
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