摘 要：
随着中药在全球范围内的应用日益广泛，其安全性评价受到了世界各国政府和科研机构的高度重视。类器官技术，作为一种模拟人体器官微环境的新兴技术，为中药的毒性评价提供了新的思路和方法。本研究采用类器官芯片技术，模仿多个人体器官的生理和病理状态，系统评估了几种主要中药成分的毒性反应。通过模拟肝脏、肾脏和心脏等重要器官的微环境，观察不同成分在这些微环境中的作用，揭示了其潜在的毒理机制。研究结果表明，类器官技术能够有效识别中药成分的细胞毒性和组织特异性反应，为中药的安全性评价提供了更为精确和科学的数据支持。此外，类器官技术在预测中药慢性毒性及其长期影响方面展现出独特优势。本研究的成果不仅有助于提高中药安全性评价的科学性和准确性，也为类器官技术在新药开发中的应用开辟了新的路径。此摘要结构清晰，按照研究背景、研究方法、研究结果和研究意义四个部分进行组织，旨在明确展示类器官技术在中药毒性评价中的应用价值。
关键词：类器官技术; 中药毒性; 安全评价
Abstract:
With the increasing global application of traditional Chinese medicine (TCM), its safety evaluation has garnered significant attention from governments and research institutions worldwide. Organoid technology, as an emerging approach that mimics the microenvironment of human organs, offers new insights and methodologies for toxicity evaluation of TCM. This study employed organoid-on-a-chip technology to simulate the physiological and pathological states of multiple human organs, systematically assessing the toxic responses of several major TCM components. By replicating the microenvironments of vital organs such as the liver, kidneys, and heart, the study observed the effects of different components within these microenvironments and unveiled their potential toxicological mechanisms. The results indicate that organoid technology can effectively identify the cytotoxicity and tissue-specific reactions of TCM components, providing more precise and scientific data to support the safety evaluation of TCM. Additionally, organoid technology demonstrates unique advantages in predicting the chronic toxicity and long-term effects of TCM. The findings of this study not only contribute to enhancing the scientific accuracy of TCM safety evaluations but also open new avenues for the application of organoid technology in new drug development. This abstract is clearly structured, organized into four sections: research background, research methods, research results, and research significance, aiming to explicitly demonstrate the application value of organoid technology in toxicity evaluation of TCM.
Keywords: Organoid technology; Toxicity of traditional Chinese medicine; Safety evaluation
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