摘 要：
传统中医方剂在肿瘤治疗中发挥着重要作用，其独特的多靶点作用机制使其在现代医学中备受关注。然而，目前对经典方剂抗肿瘤作用机制的研究大多集中于分子水平，尤其对于其表观遗传调控机制的探索尚处于初级阶段。本研究以经典方剂为研究对象，系统梳理其在肿瘤治疗中的关键作用机制，并聚焦表观遗传调控这一领域，从DNA甲基化、组蛋白修饰及非编码RNA等调控层面探讨经典方剂如何影响肿瘤细胞的增殖、凋亡及迁移等生物学行为。通过体内和体外实验验证了经典方剂对肿瘤相关表观遗传标记基因的调控作用，发现其能够显著延缓肿瘤进展，并协同传统化疗药物提高治疗效果。此外，本研究构建了经典方剂与表观遗传调控网络的整体框架，揭示了方剂中不同活性成分在调控基因表达和抗肿瘤过程中的协同效应。这些发现不仅深化了经典方剂在表观遗传调控方面的研究，还为开发创新性抗肿瘤策略提供科学依据，并开启了中医药与现代医学交叉研究的新方向。
关键词：经典方剂；抗肿瘤；表观遗传调控
Abstract:
Traditional Chinese herbal formulas play a significant role in tumor treatment, and their unique multi-target mechanisms have garnered considerable attention in modern medicine. However, current research on the anti-tumor mechanisms of classical Chinese herbal formulas mostly focuses on the molecular level, with explorations into their epigenetic regulation mechanisms still in their infancy. This study takes classical Chinese herbal formulas as the research object, systematically summarizes their key mechanisms in tumor treatment, and concentrates on the field of epigenetic regulation. It investigates how classical Chinese herbal formulas influence the biological behaviors of tumor cells, such as proliferation, apoptosis, and migration, from the regulatory levels of DNA methylation, histone modification, and non-coding RNAs. Through in vivo and in vitro experiments, the regulatory effects of classical Chinese herbal formulas on tumor-related epigenetic marker genes were verified. It was found that they can significantly delay tumor progression and synergize with traditional chemotherapy drugs to enhance therapeutic efficacy. In addition, this study constructed an overall framework of the epigenetic regulation network of classical Chinese herbal formulas, revealing the synergistic effects of different active components in the formulas in regulating gene expression and the anti-tumor process. These findings not only deepen the research on the epigenetic regulation aspects of classical Chinese herbal formulas but also provide a scientific basis for the development of innovative anti-tumor strategies, opening up a new direction for interdisciplinary research between traditional Chinese medicine and modern medicine.
Keywords: Classical Chinese herbal formulas; Anti-tumor; Epigenetic regulation
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