摘 要：
在个性化医疗背景下，中药制剂的精准化、定制化需求日益增长。然而，传统中药制剂的生产工艺和形式难以满足现代化健康管理的高度个性化需求。3D生物打印技术是一项集材料科学、生物工程和智能制造于一体的新兴技术，其在药物制剂领域的应用潜力备受关注。本研究旨在探讨3D生物打印技术在中药制剂个性化定制中的应用前景，通过分析当前技术的发展现状与瓶颈，以及中药制剂的特点与需求之间的关系，提出该技术结合中药学领域的创新策略。研究表明，通过3D生物打印技术，中药制剂可实现剂型定制、精确剂量控制以及多组分协同作用的优化，从而提高药物利用率及治疗效果。此外，该技术还能满足患者的个体化需求，例如依托药物与基质的灵活设计实现药物释放速率可调，以及采用可溶性或生物兼容材料制作个性化服药器具。尽管目前尚存在中药生物墨水开发、打印精度提升以及成本控制等技术挑战，但从长远来看，3D生物打印将推动中药制剂个性化定制的发展。研究结果为中药制剂与现代智能制造技术的深度融合提供了理论支持和技术参考，为中药现代化和个性化医疗的实现奠定了新的基础。
关键词：3D生物打印技术；中药制剂；个性化定制；精准剂量控制
Abstract:
In the context of personalized medicine, the demand for precise and customized traditional Chinese medicine (TCM) preparations is increasing. However, the traditional production processes and forms of TCM preparations struggle to meet the highly personalized needs of modern health management. 3D bioprinting technology is an emerging technology that integrates materials science, bioengineering, and intelligent manufacturing. Its application potential in the field of pharmaceutical preparations has attracted significant attention. This study aims to explore the application prospects of 3D bioprinting technology in the personalized customization of TCM preparations. By analyzing the current development status and bottlenecks of the technology, as well as the relationship between the characteristics and needs of TCM preparations, innovative strategies for combining this technology with the field of traditional Chinese pharmacy are proposed. Research indicates that through 3D bioprinting technology, TCM preparations can achieve dosage form customization, precise dosage control, and optimization of the synergistic effects of multiple components, thereby improving drug utilization efficiency and therapeutic outcomes. In addition, this technology can meet the individualized needs of patients. For example, flexible design of drugs and matrices enables adjustable drug release rates, and soluble or biocompatible materials can be used to fabricate personalized medication administration devices. Despite the current technical challenges, such as the development of TCM bioinks, improvement of printing precision, and cost control, in the long run, 3D bioprinting will promote the development of personalized customization of TCM preparations. The research results provide theoretical support and technical references for the deep integration of TCM preparations with modern intelligent manufacturing technologies, laying a new foundation for the modernization of TCM and the realization of personalized medicine.
Keywords: 3D bioprinting technology; Traditional Chinese Medicine preparations; Personalized customization; Precise dosage control
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