In the context of globalization, engineering technology management is facing unprecedented challenges and opportunities. This paper aims to explore the impact of globalization on engineering technology management, analyze the current challenges, and uncover potential opportunities. Through a deep analysis of globalization trends, combined with practical cases of engineering technology management, this paper conducts a comprehensive study from multiple dimensions such as market environment, technological innovation, talent management, and cross-cultural communication. The study finds that globalization has brought challenges such as intensified market competition, rapid technological iteration, and diversified talent, but it also provides opportunities for engineering technology management such as international cooperation, resource sharing, and market expansion. In response to these challenges and opportunities, this paper proposes a series of strategies to help engineering technology managers better seize opportunities and address challenges in the context of globalization.